HOMA-IR level in obese type 2 diabetic rat model treated by Sleeve gastrectomy and pancreatic omentoplasty

Obesity is a health problem that occurs due to the wrong lifestyle, such as lack of physical activity and diet. Accumulation adipose tissue in obesity may increases pro-inflammatory cytokines, particularly pancreatic beta cells leading type 2 diabetes mellitus (T2DM). Sleeve gastrectomy (SG) an alternative therapy for T2DM obese patients by losing about 40-60% body weight increasing GLP-1 secretion which stimulates increased insulin secretion. However, SG procedure cannot reduce cytokines promote damaged cells. Pancreatic omentoplasty can suppress regeneration The goal this study investigate HOMA-IR rats with who underwent procedures. An experimental using pre post-test control group design were done study. Eighteen Diabetes Mellitus divided into 3 groups: K1 (SG), K2 (SG + Omentoplasty), K3 (control). Blood glucose level measured glucoDR Glucometer Bio-sensor kit ELISA, respectively before 10 days after procedure. measurement was calculated based on blood level. A significant decrease fasting gluocese levels shown all treatment groups day 10th. There increase Highest K2. Furthermore, From study, we conclude Pancreas Omentoplasty significantly value T2DM.